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    • Scientific and Clinical Research on Turmeric and Hemochromatosis

    Clinical Research for Turmeric (“Curcumin”) and Iron:
    • Srichairatanakool, S., Thephinlap, C., Phisalaphong, C., Porter, J. B., and Fucharoen, S. Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. Med.Chem. 2007;3(5):469-474.
    • Jiao, Y., Wilkinson, J., Christine, Pietsch E., Buss, J. L., Wang, W., Planalp, R., Torti, F. M., and Torti, S. V. Iron chelation in the biological activity of curcumin. Free Radic.Biol.Med. 4-1-2006;40(7):1152-1160.
    • Jiao, Y., Wilkinson, J., Di, X., Wang, W., Hatcher, H., Kock, N. D., D’Agostino, R., Jr., Knovich, M. A., Torti, F. M., and Torti, S. V. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 1-8-2009;113(2):462-469.
    • Tuntipopipat, S., Zeder, C., Siriprapa, P., and Charoenkiatkul, S. Inhibitory effects of spices and herbs on iron availability. Int.J Food Sci.Nutr. 2009;60 Suppl 1:43-55.
    • Tuntipopipat, S., Judprasong, K., Zeder, C., Wasantwisut, E., Winichagoon, P., Charoenkiatkul, S., Hurrell, R., and Walczyk, T. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. J Nutr. 2006;136(12):2970-2974.
    • Baum, L. and Ng, A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models. J Alzheimers.Dis. 2004;6(4):367-377.
    • Ishihara, M. and Sakagami, H. Re-evaluation of cytotoxicity and iron chelation activity of three beta-diketones by semiempirical molecular orbital method. In Vivo 2005;19(1):119-123.
    • Bernabe-Pineda, M., Ramirez-Silva, M. T., Romero-Romo, M. A., Gonzalez-Vergara, E., and Rojas-Hernandez, A. Spectrophotometric and electrochemical determination of the formation constants of the complexes Curcumin-Fe(III)-water and Curcumin-Fe(II)-water. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2004;60(5):1105-1113.
    • Reddy, A. C. and Lokesh, B. R. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem.Toxicol 1994;32(3):279-283.
    • Reddy, A. C. and Lokesh, B. R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol.Cell Biochem. 8-17-1994;137(1):1-8.
    • Reddy, A. C. and Lokesh, B. R. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 1-22-1996;107(1):39-45.
    • Mandel, S., Amit, T., Bar-Am, O., and Youdim, M. B. Iron dysregulation in Alzheimer’s disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog.Neurobiol. 2007;82(6):348-360.
    • Jyoti, A., Sethi, P., and Sharma, D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav. 2009;14(2):300-308.
    • Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. B., and Srichairatanakool, S. Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids. Med Chem 2011;7(1):62-69.
    • Thephinlap C, Phisalaphong C, Fucharoen S, Porter JB, Srichairatanakool S.Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice. Med Chem. 2009 Sep;5(5):474-82.

    Topical Application of Turmeric Studies:

    • Hegge AB1, Schüller RB, Kristensen S, Tønnesen HH. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie. 2008 Aug;63(8):585-92.
    • Teichmann A1, Heuschkel S, Jacobi U, Presse G, Neubert RH, Sterry W, Lademann J. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur J Pharm Biopharm. 2007 Nov;67(3):699-706.
    • (**Note: In respect to the above study, our Turmeric Cream is a “microemulsion” preparation and not a “amphiphillic” preparation)
    • Fang JY1, Hung CF, Chiu HC, Wang JJ, Chan TF. Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. J Pharm Pharmacol. 2003 May;55(5):593-601.
    • Fang JY1, Hung CF, Chiu HC, Wang JJ, Chan TF. Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. J Pharm Pharmacol. 2003 Aug;55(8):1175.
    • Patel NA1, Patel NJ, Patel RP. Design and evaluation of transdermal drug delivery system for curcumin as an anti-inflammatory drug. Drug Dev Ind Pharm. 2009 Feb;35(2):234-42.
    • H Moghimi, B Shahmir, A Zarghi. Enhancement of percutaneous absorption of curcumin (turmeric pigment) by ethanol. IJPR. Iranian Journal of Pharmaceutical Research. Article 21, Volume 3, Supplement 2, Autumn 2004, Pages 8-9.
    • (**Note: In respect to the above study, our Turmeric Cream contains alcohol as an ingredient to enhance absorption)