Health Benefits of Quercetin and Resveratrol in Hemochromatosis
The Hemochromatosis Help Quercetin and Resveratrol Complex provides a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. These three polyphenol-rich antioxidants work together synergistically and are being extensively studied in the areas of cardiovascular health and aging.
For a person with hemochromatosis, these powerful health promoting nutrients may also help reduce elevated levels of iron, protect from oxidative damage, and protect the heart and liver from damage due to excess iron!
Antioxidants For Health and Wellness
Quercetin is a bioflavonoid antioxidant found in many nutrient-rich fruits and vegetables, and is especially high in red onions and apples. Studies have shown it may play an important role in fighting free-radical damage, reducing inflammation, fighting allergies, supporting heart health, and protecting liver health.
Resveratrol, famously coming from red wine, is also found in richly-colored berries and dark chocolate. It is considered one of nature’s most powerful polyphenols and is a well renowned nutrient demonstrating a wide range of support to our overall health. Resveratrol possesses strong anti-inflammatory and antioxidant effects and is known to positively modulate healthy gene expression, including the genes associated with longevity and a healthy life span. Resveratrol may also be protective of heart health, important for brain and mental health, and important in diabetes and prediabetes.
Pterostilbene, found in antioxidant-rich foods like blueberries and grapes, has a similar structure and similar health benefits as resveratrol. Pterostilbene, however, is more easily absorbed and used by the body than its cousin resveratrol, and serves to complement the resveratrol and quercetin in this formula for a true synergistic effect.
Quercetin’s Influence on Iron Markers
Quercetin positively influences many of the key iron-regulating pathways of the body, including the hormone hepcidin, the primary hormone responsible for maintaining proper iron levels. In hemochromatosis, hepcidin levels are low due to genetic factors. As a result of low hepcidin, the body absorbs more iron.
Quercetin has been demonstrated to raise hepcidin, while also lowering serum iron and transferrin saturation:
“Quercetin and related polyphenols such as EGCG may reduce iron toxicity by chelation or by preventing its release/efflux from cells. It was particularly intriguing that of all the compounds tested, quercetin had the most dramatic effect on post-prandial hepcidin induction, serum iron and transferrin saturation. This may partly explain their ability to reduce iron overload in haemochromatosis.” - Free Radic Biol Med. 2015 Dec;89:1192-202.
Resveratrol Protects the Heart and Liver
Resveratrol has its own impressive list of research demonstrating its benefits to iron overload. The liver is the organ most often at risk in hemochromatosis. Excess iron in the liver can lead to many negative effects, such as damage from oxidative stress and inflammation, fibrosis, and liver damage.
One study from 2016 concluded that “resveratrol treatment directly protects the liver from iron-mediated injury...Our findings illustrate a novel and definitive therapeutic action of resveratrol and represent an economically feasible therapeutic intervention to treat hepatic iron-overload and liver disease." Liver Int. 2016 Feb;36(2):246-57.
Similarly, resveratrol is also protective to the heart and cardiovascular system that has been negatively affected by excess iron levels. “Resveratrol represents a clinically and economically feasible therapeutic intervention to reduce the global burden from iron-overload cardiomyopathy at early and chronic stages of iron-overload.” Sci Rep. 2015 Dec 7;5:18132.
Overall Health Benefits from Quercetin and Resveratrol
Quercetin and resveratrol are both powerful antioxidants in their own right, yet their synergy may make them even stronger together as a pair. Quercetin and resveratrol possess a strong ability to protect cells from iron overload, while simultaneously supporting overall health and well-being.
Dietary consumption of quercetin is a fraction of what can be found in a supplement, and one capsule of resveratrol is equivalent to 60 glasses of red wine!
As illustrated in the figure, clinical research has documented that as cellular quercetin levels rise, ferritin levels decrease, so the amount consumed is important.
How to use Hemochromatosis Help's Quercetin and Resveratrol Complex
Suggested Use: 1 capsule, 1-2 times daily
Does Not Contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
Quality and Safety of Our Hemochromatosis Help Supplements
We have incredibly high standards when it comes to the quality and safety of nutritional supplements. We have not and will not take any shortcuts when it comes to the products available through this website!
All of the nutritional products with our name on them are manufactured in the USA in an FDA-approved pharmaceutical-grade laboratories with verified 3rd-party testing.
The ingredients are sourced from the best raw materials based on quality, purity, and research.
The manufacturer has been Good Manufacturing Practice (GMP) registered by the independent third-party National Sanitation Foundation (NSF International).
Product certification ensures that what’s on the supplement label is in the bottle and that the product contains no undeclared ingredients or unsafe levels of contaminants.
All products are manufactured in the USA in an FDA GMP compliant factory.