The Hemochromatosis Help Quercetin and Resveratrol Complex provides a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. These three polyphenol-rich antioxidants work together synergistically and are being extensively studied in the areas of cardiovascular health and aging.
For a person with hemochromatosis, these powerful health promoting nutrients may also help reduce elevated levels of iron, protect from oxidative damage, and protect the heart and liver from damage due to excess iron!
Quercetin positively influences many of the key iron-regulating pathways of the body, including the hormone hepcidin, the primary hormone responsible for maintaining proper iron levels. In hemochromatosis, hepcidin levels are low due to genetic factors. As a result of low hepcidin, the body absorbs more iron.
Quercetin has been demonstrated to raise hepcidin, while also lowering serum iron and transferrin saturation:
“Quercetin and related polyphenols such as EGCG may reduce iron toxicity by chelation or by preventing its release/efflux from cells. It was particularly intriguing that of all the compounds tested, quercetin had the most dramatic effect on post-prandial hepcidin induction, serum iron and transferrin saturation. This may partly explain their ability to reduce iron overload in haemochromatosis.” - Free Radic Biol Med. 2015 Dec;89:1192-202.
Resveratrol has its own impressive list of research demonstrating its benefits to iron overload. The liver is the organ most often at risk in hemochromatosis. Excess iron in the liver can lead to many negative effects, such as damage from oxidative stress and inflammation, fibrosis, and liver damage.
One study from 2016 concluded that “resveratrol treatment directly protects the liver from iron-mediated injury...Our findings illustrate a novel and definitive therapeutic action of resveratrol and represent an economically feasible therapeutic intervention to treat hepatic iron-overload and liver disease." Liver Int. 2016 Feb;36(2):246-57.
Similarly, resveratrol is also protective to the heart and cardiovascular system that has been negatively affected by excess iron levels. “Resveratrol represents a clinically and economically feasible therapeutic intervention to reduce the global burden from iron-overload cardiomyopathy at early and chronic stages of iron-overload.” Sci Rep. 2015 Dec 7;5:18132.
Quercetin and resveratrol are both powerful antioxidants in their own right, yet their synergy may make them even stronger together as a pair. Quercetin and resveratrol possess a strong ability to protect cells from iron overload, while simultaneously supporting overall health and well-being.
Dietary consumption of quercetin is a fraction of what can be found in a supplement, and one capsule of resveratrol is equivalent to 60 glasses of red wine!
As illustrated in the figure, clinical research has documented that as cellular quercetin levels rise, ferritin levels decrease, so the amount consumed is important.
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