Scientific Research on Quercetin and Resveratrol and Hemochromatosis

Scientific Research on Quercetin and Iron Overload

  • Bayele HK, Balesaria S, Srai SK. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption. Free Radic Biol Med. 2015 Dec;89:1192-202. doi: 10.1016/j.freeradbiomed.2015.11.001. Epub 2015 Nov 10. PMID: 26546695; PMCID: PMC4698393.
  • El-Sheikh AA, Ameen SH, AbdEl-Fatah SS. Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine. J Toxicol. 2018;2018:8023840. Published 2018 Nov 21. doi:10.1155/2018/8023840. PMID: 30584425
  • Guo M, Perez C, Wei Y, et al. Iron-binding properties of plant phenolics and cranberry’s bio-effects. Dalton Trans. 2007 Nov 21 (43):4951-61. PubMed PMID: 17992280.
  • Kim JK, Park SU. Quercetin and its role in biological functions: an updated review. EXCLI J. 2018;17:856-863. Published 2018 Aug 27. doi:10.17179/excli2018-1538. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141818/
  • Leopoldini M, Russo N, Chiodo S, Toscano M. Iron chelation by the powerful antioxidant flavonoid quercetin. J Agric Food Chem. 2006 Aug 23;54(17):6343-51. doi: 10.1021/jf060986h. PMID: 16910729.
  • Lesjak M, Balesaria S, Skinner V, Debnam ES, Srai SKS. Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues. Eur J Nutr. 2019;58(2):743-753. doi:10.1007/s00394-018-1680-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437293/
  • Lesjak M, Hoque R, Balesaria S, Skinner V, Debnam ES, Srai SKS, et al. (2014) Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro. PLoS ONE 9(7): e102900. https://doi.org/10.1371/journal.pone.0102900
  • Mladenka P, Macakova K, Filipsky T, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011 May;105(5):693-701. PubMed PMID: 21450273.
  • Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F. The effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trial. Complement Ther Med. 2019 Oct;46:24-28. doi: 10.1016/j.ctim.2019.02.017. Epub 2019 Feb 26. PMID: 31519283.
  • Zhang Y, Gao Z, Liu J, Xu Z. Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues. Nat Prod Res. 2011 Jul;25(12):1150-60. https://pubmed.ncbi.nlm.nih.gov/21740280/
  • Zhang Y, Li H, Zhao Y, Gao Z. Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury. Eur J Pharmacol. 2006 Mar 27;535(1-3):263-9. https://pubmed.ncbi.nlm.nih.gov/16527270/