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  • Scientific Research on Quercetin and Resveratrol and Hemochromatosis

    Scientific Research on Quercetin and Iron Overload

    • Bayele HK, Balesaria S, Srai SK. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption. Free Radic Biol Med. 2015 Dec;89:1192-202. doi: 10.1016/j.freeradbiomed.2015.11.001. Epub 2015 Nov 10. PMID: 26546695; PMCID: PMC4698393.
    • El-Sheikh AA, Ameen SH, AbdEl-Fatah SS. Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine. J Toxicol. 2018;2018:8023840. Published 2018 Nov 21. doi:10.1155/2018/8023840. PMID: 30584425
    • Guo M, Perez C, Wei Y, et al. Iron-binding properties of plant phenolics and cranberry’s bio-effects. Dalton Trans. 2007 Nov 21 (43):4951-61. PubMed PMID: 17992280.
    • Kim JK, Park SU. Quercetin and its role in biological functions: an updated review. EXCLI J. 2018;17:856-863. Published 2018 Aug 27. doi:10.17179/excli2018-1538. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141818/
    • Leopoldini M, Russo N, Chiodo S, Toscano M. Iron chelation by the powerful antioxidant flavonoid quercetin. J Agric Food Chem. 2006 Aug 23;54(17):6343-51. doi: 10.1021/jf060986h. PMID: 16910729.
    • Lesjak M, Balesaria S, Skinner V, Debnam ES, Srai SKS. Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues. Eur J Nutr. 2019;58(2):743-753. doi:10.1007/s00394-018-1680-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437293/
    • Lesjak M, Hoque R, Balesaria S, Skinner V, Debnam ES, Srai SKS, et al. (2014) Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro. PLoS ONE 9(7): e102900. https://doi.org/10.1371/journal.pone.0102900
    • Mladenka P, Macakova K, Filipsky T, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011 May;105(5):693-701. PubMed PMID: 21450273.
    • Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F. The effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trial. Complement Ther Med. 2019 Oct;46:24-28. doi: 10.1016/j.ctim.2019.02.017. Epub 2019 Feb 26. PMID: 31519283.
    • Zhang Y, Gao Z, Liu J, Xu Z. Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues. Nat Prod Res. 2011 Jul;25(12):1150-60. https://pubmed.ncbi.nlm.nih.gov/21740280/
    • Zhang Y, Li H, Zhao Y, Gao Z. Dietary supplementation of baicalin and quercetin attenuates iron overload induced mouse liver injury. Eur J Pharmacol. 2006 Mar 27;535(1-3):263-9. https://pubmed.ncbi.nlm.nih.gov/16527270/

    Scientific Research on Resveratrol and Iron Overload

      • Bayele HK, Balesaria S, Srai SK. Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption. Free Radic Biol Med. 2015 Dec;89:1192-202. doi:10.1016/j.freeradbiomed.2015.11.001. Epub 2015 Nov 10. PMID: 26546695.
      • Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY. Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy. Sci Rep. 2015 Dec 7;5:18132. doi: 10.1038/srep18132. PubMed PMID:26638758.
      • Das SK, DesAulniers J, Dyck JR, Kassiri Z, Oudit GY. Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload. Liver Int. 2016 Feb;36(2):246-57. doi: 10.1111/liv.12893. Epub 2015 Jul 3. PubMed PMID: 26077449.
      • Galtieri A, Tellone E, Ficarra S, et al. Resveratrol treatment induces redox stress in red blood cells: a possible role of caspase 3 in metabolism and anion transport. Biol Chem. 2010;391(9):1057‐1065. doi:10.1515/BC.2010.100 PMID: 20536388
      • Granzotto A, Zatta P. Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition. Front Aging Neurosci. 2014 May 14;6:95. doi: 10.3389/fnagi.2014.00095. PMID: 24860502
      • Imam MU, Zhang S, Ma J, Wang H, Wang F. Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress. Nutrients. 2017 Jun 28;9(7):671. doi: 10.3390/nu9070671. PMID: 28657578.
      • Kwon KJ, Kim JN, Kim MK, Lee J, Ignarro LJ, Kim HJ, Shin CY, Han SH. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res. 2011 Mar;50(2):110-23. doi:10.1111/j.1600-079X.2010.00820.x. Epub 2010 Nov 15. PubMed PMID: 21073519.
      • Milman NT. Managing Genetic Hemochromatosis: An Overview of Dietary Measures, Which May Reduce Intestinal Iron Absorption in Persons With Iron Overload. Gastroenterology Res. 2021 Apr;14(2):66-80. doi: 10.14740/gr1366. Epub 2021 Apr 21. PMID: 34007348
      • Patrick Rhonda: https://www.foundmyfitness.com/topics/resveratrol
      • Wikipedia, "Heme Oxygenase", https://en.wikipedia.org/wiki/Heme_oxygenase, Accessed December 2021.